16" XLarge Cheese Pizza
Prepared dough with our signature sauce and a generous layer of cheese, creating a classic 16" cheese pizza.
Classic
Chillicothe's Cheese Champion
Made with our signature sauce, and a ridiculous amount of cheese - delivered hot to your door or for pick up at ours at 957 East Main Street, Chillicothe, OH.
Order Online
Fan Favorites
The Pies That Built the Reputation
12" Medium BBQ Chicken Pizza
BBQ sauce base with grilled chicken, crispy bacon, and a blend of cheeses. Drizzle of BBQ sauce after cooking.
Smoky
14" Large All the Way
Pizza sauce, cheese, ham, bacon, sausage, pepperoni, mushrooms, onions, green peppers, banana peppers and black olives.
Loaded
14" Large Cheese Pizza
Prepared dough with our signature sauce and a generous layer of cheese, creating a classic 14" cheese pizza.
Classic
12" Medium Cheese
Prepared dough with our signature sauce and a generous layer of cheese, creating a classic 12" cheese pizza.
Personal
16" X Large Chicken Bacon Ranch Pizza
Ranch dressing base with grilled chicken, crispy bacon, and a blend of cheeses on a 16-inch pizza crust.
Crowd Pleaser
Straight From Main Street
Our Story
Main Street Pizza is Chillicothe's hometown pizzeria - unpretentious, prepared dough, and proudly loaded with cheese. Every pie starts with our prepared dough and our signature sauce, then gets stacked with generous, quality toppings the way pizza should be. From simple classic cheese to the fully loaded All the Way, we fire each order hot and get it out the door fast. Locals call us their new favorite for a reason. Come taste the pizza Chillicothe, OH can't stop talking about.
Word on Main Street
4.7★
Rated by 678 hungry locals
“
Absolutely amazing! The BEST pizza in town by far and I've tried them all! The freshness of the ingredients were top quality. Portions are fantastic! I will buy again, frequently! My family is a major fan of this business now.
Renay D
“
Just moved back after living in Texas for decades so first time I have ordered from Main St Pizza. . THIS is what pizza should be! Ordered a 14" LARGE CHEESE PIZZA with half pepperoni. Tastes great, ridiculously good amount of cheese and was delivered hot. Think I have a new favorite pizza place!
Stacy W
“
We had a sub and pizza! They have 2 sizes of subs and a lotta different specialty pizzas! Both had generous portions of toppings and were very tasty!!! Very good customer service!!My new favorite pizza place!!
Tonita J
Good to Know
FAQ
What meals do you serve?
Main Street Pizza serves pizzas perfect for family dinners, casual lunches, and group gatherings in Chillicothe, OH. Our menu features classic cheese pizzas in 8", 10" 12", 14", and 16" sizes, all made with prepared dough and our signature sauce. Meat lovers enjoy the 14" Large All the Way, loaded with ham, bacon, sausage, pepperoni, mushrooms, onions, green peppers, banana peppers, and black olives. For something bold, our 12" Medium BBQ Chicken Pizza combines grilled chicken, crispy bacon, and a smoky BBQ sauce drizzle. Whether you crave a simple classic or a fully loaded pie, Main Street Pizza has you covered, everything made fresh to your order!
Do you offer delivery or takeout?
Yes, we offer both delivery and pickup. Order conveniently by calling us directly 740-774-3700 or use online ordering through our website.
Where are you located?
Main Street Pizza is located at 957 E Main St, Chillicothe, OH 45601, United States.
What areas do you serve?
Main Street Pizza proudly serves Chillicothe and Ross County - We have customers from surrounding areas including Frankfort, Waverly, Circleville, McArthur, Jackson, Piketon, Bainbridge, Hillsboro, Washington Court House, and Londonderry, OH.
Find Us
Visit Us
957 E Main St
Chillicothe, OH 45601
United States
Chillicothe, OH 45601
United States
Delivery & Pickup Available
When We're Firing the Oven
- Mon
- 10:00 AM - 9:00 PM
- Tue
- 10:00 AM - 9:00 PM
- Wed
- 10:00 AM - 9:00 PM
- Thu
- 10:00 AM - 9:00 PM
- Fri
- 10:00 AM - 10:00 PM
- Sat
- 10:00 AM - 10:00 PM
- Sun
- 12:00 PM - 8:00 PM
Order online
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